Proliferative senescence in hematopoietic stem cells during ex-vivo expansion.
نویسندگان
چکیده
The good outcome of hematopoietic stem cell (HSC) transplantation is hampered by low doses of CD34+ cell infusion. Transplanted HSCs undergo a replicative stress that causes accelerated senescence due to rapid telomere shortening. The expansion of human cord blood HSCs is instrumental in obtaining a large number of "good quality" cells, in terms of telomere length and telomerase activity compared to adult HSCs.
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ورودعنوان ژورنال:
- Folia histochemica et cytobiologica
دوره 43 4 شماره
صفحات -
تاریخ انتشار 2005